Centrilobular Emphysema and Coronary Artery Calcification: Mediation Analysis in the SPIROMICS Cohort

Authors

Surya P. Bhatt, University Of Alabama At Birmingham
Hrudaya P. Nath, University Of Alabama At Birmingham
Young-Il Kim, University Of Alabama At Birmingham
Rekha Ramachandran, University Of Alabama At Birmingham
Jubal R. Watts, University Of Alabama At Birmingham
Nina L.J. Terry, University Of Alabama At Birmingham
Sushil Sonavane, University Of Alabama At Birmingham
Swati P. Deshmane, University Of Alabama At Birmingham
Prescott G. Woodruff, University of California, San Francisco
Elizabeth C. Oelsner, Columbia University Medical Center
Sandeep Bodduluri, University Of Alabama At Birmingham
MeiLan K. Han, University of Michigan - Ann Arbor
Wassim W. Labaki, University of Michigan - Ann Arbor
J. Michael Wells, University Of Alabama At Birmingham
Fernando J. Martinez, Weill Cornell School of Medicine
R. Graham Barr, Columbia University Medical Center
Mark T. Dransfield, University Of Alabama At Birmingham
SPIROMICS investigators

Document Type

Article

Journal Title

Respiratory Research

Publication Date

2018

Volume

19

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with a two-to-five fold increase in the risk of coronary artery disease independent of shared risk factors. This association is hypothesized to be mediated by systemic inflammation but this link has not been established.

METHODS: We included 300 participants enrolled in the SPIROMICS cohort, 75 each of lifetime non-smokers, smokers without airflow obstruction, mild-moderate COPD, and severe-very severe COPD. We quantified emphysema and airway disease on computed tomography, characterized visual emphysema subtypes (centrilobular and paraseptal) and airway disease, and used the Weston visual score to quantify coronary artery calcification (CAC). We used the Sobel test to determine whether markers of systemic inflammation mediated a link between spirometric and radiographic features of COPD and CAC.

RESULTS: FEV

CONCLUSIONS: The association between airflow obstruction and coronary calcification is driven primarily by the centrilobular subtype of emphysema, and is linked through bioactive molecules implicated in the pathogenesis of atherosclerosis.

TRIAL REGISTRATION: ClinicalTrials.gov: Identifier: NCT01969344 .

MeSH Headings

Aged, Biomarkers, Cohort Studies, Coronary Artery Disease, Female, Humans, Inflammation Mediators, Male, Middle Aged, Outcome Assessment, Health Care, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Smoking, Vascular Calcification, Vital Capacity

DOI Link

10.1186/s12931-018-0946-1

ISSN

1465-993X

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Bhatt, Surya P.; Nath, Hrudaya P.; Kim, Young-Il; Ramachandran, Rekha; Watts, Jubal R.; Terry, Nina L.J.; Sonavane, Sushil; Deshmane, Swati P.; Woodruff, Prescott G.; Oelsner, Elizabeth C.; Bodduluri, Sandeep; Han, MeiLan K.; Labaki, Wassim W.; Wells, J. Michael; Martinez, Fernando J.; Barr, R. Graham; Dransfield, Mark T.; and SPIROMICS investigators, "Centrilobular Emphysema and Coronary Artery Calcification: Mediation Analysis in the SPIROMICS Cohort" (2018). Journal Articles: Pulmonary & Critical Care Med. 36.
https://digitalcommons.unmc.edu/com_pulm_articles/36