Document Type
Article
Journal Title
Pulmonary Medicine
Publication Date
Fall 10-1-2013
Volume
2013
Abstract
Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NO x ). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC NO x concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μ M versus after = 37 ± 17 μ M; P < 0.002). CF subjects had a trend toward lower EBC NO x . Conclusion. We found an association between VCPT-stimulated clearance and exhaled NO x levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism.
DOI Link
ISSN
2090-1836
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Recommended Citation
Sisson, Joseph H.; Wyatt, Todd A.; Pavlik, Jacqueline A.; Sarna, Pawanjit S.; and Murphy, Peter J., "Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism." (2013). Journal Articles: Pulmonary & Critical Care Med. 7.
https://digitalcommons.unmc.edu/com_pulm_articles/7
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