Document Type
Article
Journal Title
Advanced Therapeutics
Publication Date
2025
Abstract
Effective and safe antibiotics active against pathogenic mycobacterial species are needed. Iron is an essential element for bacterial survival. Ga(NO3)3 (GN) and Ga protoporphyrin (GP) as iron mimetics have each been shown to inhibit the iron metabolism and growth of various mycobacterial species. In this study, the dual cyclodextrin nanoparticle (CDGPGN) is prepared that carries GP and GN using a sonication homogenization technique to increase the efficacy of the combination therapy. CDGPGN shows a long-acting antimicrobial activity against Mycobacteroides abscessus residing in monocyte-derived macrophages (MDM). A murine pulmonary study showed that the CDGPGN also inhibited the growth of M. abscessus and M. avium complex (MAC) in the lungs. GP induced mycobacterial superoxide dismutase (SOD) activity and reduced catalase activity. GN neither reduces nor increases SOD and catalase activities in mycobacteria. This study confirms that dual CDGPGN nanoparticles containing both GN and GP have potential for development as antimycobacterial agents against M. abscessus.
DOI Link
ISSN
2366-3987
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Choi, Seoung-Ryoung; Britigan, Bradley E.; and Narayanasamy, Prabagaran, "Gallium β-Cyclodextrin Nanoparticles Containing both Gallium Protoporphyrin and Gallium Nitrate Exhibit Antimicrobial Activity against Nontuberculous Mycobacteria in Vitro and in Vivo" (2025). Journal Articles: Pulmonary & Critical Care Med. 93.
https://digitalcommons.unmc.edu/com_pulm_articles/93
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