Document Type
Capstone Experience
Graduation Date
8-2021
Degree Name
Master of Public Health
Department
Biostatistics
First Committee Member
Jane Meza PhD
Second Committee Member
Kendra Schmid PhD
Third Committee Member
Jerry Zimmerman MD, PhD
Abstract
Despite reductions in sepsis mortality, there remains a substantial morbidity burden among children who survive sepsis. Furthermore, the majority develop multiple organ ‘group has historically been analyzed as a single cohort. Using the Life After Pediatric Sepsis Evaluation (LAPSE) investigation database, we studied the association of new and progressive multiple organ dysfunction syndrome (NPMODS) with morbidity and mortality among children with septic shock. We hypothesized that NPMODS represents a distinct phenotype based on evolving organ dysfunction. There was evidence of an association but it did not reach the 0.05 level of significance. We also hypothesized and confirmed that children with acute neurological dysfunction have greater functional deterioration and mortality compared to other organ dysfunctions. In addition, an expanded definition of acute neurological dysfunction identified a larger cohort of patients with similar functional deteriorations that are both clinically and statistically significant.
Recommended Citation
Waworuntu, Rachel L., "Association of New and/or Progressive Multiple Organ Dysfunction Syndrome With Mortality and New Morbidity Among Children Encountering Septic Shock" (2021). Capstone Experience. 157.
https://digitalcommons.unmc.edu/coph_slce/157
Included in
Critical Care Commons, Pediatrics Commons, Public Health Commons