Document Type

Capstone Experience

Graduation Date

5-2022

Degree Name

Master of Public Health

Department

Biostatistics

First Committee Member

Lynette M. Smith, PhD

Second Committee Member

Christopher Wichman, PhD

Third Committee Member

Maneesh Jain, PhD

Abstract

Currently, many published animal experiments fail to include concise information regarding randomization (Festing, 2014). By not including randomization efforts in published research, the ability for one to accurately reproduce a study’s results is greatly diminished. This can be seen in randomization efforts that may be difficult to reproduce, such as poor randomization techniques and lack of documentation. Therefore, the creation of the Randomizer utilizing software R to create a user-friendly program that can enable University of Nebraska Medical Center (UNMC) researchers, among others, to create randomization schemes for research involving mice, other animal, or human subjects, and enhance documentation and reproducibility of results. The creation of a randomizer results in a consistent method of generating randomization schemes for research use. The program operates in R, utilizing R Shiny, and has the ability for the user to define randomization aspects to tailor their randomization scheme while also creating a transparent, documentation-friendly paper trail.

Festing, M. F. W. (2014). Randomized Block Experimental Designs Can Increase the Power and Reproducibility of Laboratory Animal Experiments. ILAR Journal, 55(3), 472-476. https://doi.org/10.1093/ilar/ilu045

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