Document Type

Capstone Experience

Graduation Date

12-2019

Degree Name

Master of Public Health

Department

Epidemiology

First Committee Member

Dr. Shinobu Watanabe-Galloway

Second Committee Member

Dr. Lorena Baccaglini

Abstract

Background: Endometrial cancer also referred to as uterine corpus cancer is the fourth most common cancer diagnosed among US women. It is also one of the few cancers in the US that has an increasing incidence and mortality rate. This study examined the overall and race specific age-adjusted incidence rate as well as incidence-based mortality rate of endometrial cancer in the United States from 1975-2016.

Methods: Surveillance, Epidemiology, and End Results (SEER) 1975-2016 data were used. Overall and race specific age-adjusted incidence rate, incidence-based mortality rates and 95% confidence intervals were calculated Trend graphs were created, annual average percent change and annual percent change were calculated using joinpoint regression analysis. All analyses were conducted using SEER*Stat Software.

Results: The overall age-adjusted incidence rate of endometrial cancer from 1975-2016 was estimated to 20.7 (95% CI 20.6-20.8) per 100,000 and the age-adjusted incidence-based mortality rate was 11.9 (95% CI 11.8-12) per 100,000. Among white women, the annual average percent change in the incidence-based mortality rate of endometrial cancer from 1975 through 2016 showed an overall increase of 5.4%. From 1993 till 2016 the incidence rates among African American women had increased by 2.1% per year.

Conclusion: Endometrial cancer burden is increasing especially among African American women. Developing control and prevention methods coupled with better access to appropriate care can help in reducing endometrial cancer disparity and burden.

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