ORCID ID
Graduation Date
Summer 8-14-2026
Document Type
Thesis
Degree Name
Master of Science (MS)
Programs
Genetics, Cell Biology & Anatomy
First Advisor
Peng Zhong
Second Advisor
Kyle Hewitt
Third Advisor
Sowmya Yelamanchili
Fourth Advisor
Hanjun Wang
Abstract
Alzheimer’s disease (AD) is characterized not only by cognitive decline and memory impairment but also cause significant disturbance in sleep and circadian rhythms. Sleep disturbance is increasingly recognized as both a symptom and risk factor to AD progression. Amyloid-β (Aβ) accumulation has been implicated in neuronal dysfunction and altered sleep-wake regulation. The locus coeruleus (LC), the primary source of norepinephrine in the brain, plays acritical role in arousal and sleep-wake control and may be affected earlier by pathological changes associated with AD. This study aimed to characterize sleep architecture and homeostatic sleep responses in APP-SAA-KI mice, a knock-in mouse model of AD which develops progressive Aβ pathology.
Rights
The author holds the copyright to this work and any reuse or permissions must be obtained from the author directly.
Recommended Citation
Guo, Siyin, "Sleep Disturbances Associated with Amyloid Pathology in Alzheimer’s Disease" (2026). Theses & Dissertations. 1100.
https://digitalcommons.unmc.edu/etd/1100
Included in
Behavioral Neurobiology Commons, Cell Biology Commons, Developmental Neuroscience Commons