Graduation Date

Fall 12-18-2020

Document Type

Thesis

Degree Name

Master of Science (MS)

Programs

Medical Sciences Interdepartmental Area

First Advisor

Dr. Sundaralingam (Prem) Premaraj

Second Advisor

Dr. Valmont Desa

Third Advisor

Dr. Peter Giannini

Fourth Advisor

Dr. Sung Kim

Abstract

Purpose of this study is to evaluate the success rates of secondary alveolar grafts using recombinant human bone morphogenetic protein with CBCT and to evaluate the effects of several variables on these outcomes. After our inclusion/exclusion criteria, records of 24 patients receiving secondary alveolar grafts at the University of Nebraska Medical Center were evaluated. Pre-graft and 6-month post-graft cleft volumes were measured using ITK-SNAP 3.8.0 software to determine a percent residual defect following surgery. Of the 24 patients, one was excluded as the graft surgery was deemed a failure. The patients’ gender, age, side of cleft, cleft side canine root lengths, angulations, and distance from the occlusal plane were also measured. The mean volumetric values for the pre-graft and post-graft clefts were 1049.30mm3 and 413.75mm3, respectively with a mean residual defect value of 0.32 (SD = 0.22). The difference in percent residual defect following the graft was not statistically significant for any of the variables measured, except for gender (F=10.63; DF=1,21; p=0.0037). This study showed females undergoing secondary grafts of unilateral alveolar clefts have a lower percent residual defect six months following surgery. However, the results of this study may not represent clinical outcomes and larger sample sizes may be helpful to conclude statistically significant differences between our variables.

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