Graduation Date
Summer 8-12-2022
Document Type
Thesis
Degree Name
Master of Science (MS)
Programs
Interdisciplinary Graduate Program in Biomedical Sciences
First Advisor
Richard A. Reinhardt DDS, PhD
Second Advisor
Amy C. Killeen DDS, MS
Third Advisor
Jeffrey B. Payne, DDS, MDentSc
Fourth Advisor
Thomas P. Petro, PhD
Abstract
A survey of dental hygienists in general practice (DHGP; n = 74) and periodontal practice (DHPP; n = 62) indicated a difference (p £ 0.04) in preference for interproximal cleaning with oral irrigators (DHGP) and interproximal brushes (DHPP) during periodontal maintenance therapy (PMT). The purpose of the subsequent blinded, randomized controlled clinical trial was to compare the effect of interproximal cleaning aids on reducing inflammation in posterior pockets during PMT. Seventy-six patients on PMT with a 5-7 mm interproximal probing depth were randomly allocated to one of three groups: 1) interproximal brush with tracking device (IB + TD; n=23), 2) oral irrigator (OI; n =27) or 3) interproximal brush alone (IB; n=26). Bleeding on probing (BOP), Gingival Index (GI) and gingival crevicular fluid (GCF) profiles were assessed at baseline and 6-weeks. IL-1b, IL-6, IL-17A, TNF-a, IL-4, IL-10 and IFN-g were assessed with Human Milliplex Analysis. BOP and GI were significantly reduced (p < 0.0001) in all groups with no difference among groups. There was a significantly greater reduction for IL-1b with IB + TD compared to OI (p < 0.05) and a similar trend for IL-6 (p = 0.06).
Conclusions: All groups showed improvement in GI and BOP. However, IB + TD showed more IL-1b reduction indicating that devices to encourage homecare may enhance reduction of important markers of inflammation.
Recommended Citation
Moore, Grace, "The Effect of Interproximal Home Regimens of Inflammatory Biomarkers in Periodontal Maintenance Patients" (2022). Theses & Dissertations. 663.
https://digitalcommons.unmc.edu/etd/663