The Link Between Fat Soluble Vitamin Deficiencies, Decreased Microbiota Diversity and Severity in Children with Sickle Cell Disease Followed in a Clinic in Omaha Nebraska

Author

Chinenye R. Dike, University of Nebraska Medical CenterFollow

ORCID ID

0000-0003-2435-3655

Graduation Date

Fall 12-16-2022

Document Type

Thesis

Degree Name

Master of Science (MS)

Programs

Medical Sciences Interdepartmental Area

First Advisor

H. Dele Davies MD, MS, MHCM

Second Advisor

Peter Mannon MD, MPH

Third Advisor

Corrine Hanson PhD, RD, LMNT

Fourth Advisor

Stephen Obaro MD, PhD

MeSH Headings

Fat soluble vitamins, Microbiome, Sickle Cell

Abstract

Fat soluble vitamin (FSV) deficiencies are associated with worse pain in individuals with sickle cell disease (SCD). Data on the dietary and pancreatic function influence on fat soluble vitamin levels are limited. Additionally, individuals with SCD have gut dysbiosis but there are gaps in knowledge on the impact of this on severity. This thesis attempted to evaluate FSV prevalence and gut microbial profile in our cohort of children with SCD and compare this with matched healthy children and to ascertain if diet or pancreatic function affects these levels and see if these affects sickle cell severity.

Comments

2022 Copyright, the authors

Recommended Citation

Dike, Chinenye R., "The Link Between Fat Soluble Vitamin Deficiencies, Decreased Microbiota Diversity and Severity in Children with Sickle Cell Disease Followed in a Clinic in Omaha Nebraska" (2022). Theses & Dissertations. 699.
https://digitalcommons.unmc.edu/etd/699