Graduation Date

Fall 12-16-2022

Document Type


Degree Name

Master of Science (MS)


Medical Sciences Interdepartmental Area

First Advisor

H. Dele Davies MD, MS, MHCM

Second Advisor

Peter Mannon MD, MPH

Third Advisor

Corrine Hanson PhD, RD, LMNT

Fourth Advisor

Stephen Obaro MD, PhD

MeSH Headings

Fat soluble vitamins, Microbiome, Sickle Cell


Fat soluble vitamin (FSV) deficiencies are associated with worse pain in individuals with sickle cell disease (SCD). Data on the dietary and pancreatic function influence on fat soluble vitamin levels are limited. Additionally, individuals with SCD have gut dysbiosis but there are gaps in knowledge on the impact of this on severity. This thesis attempted to evaluate FSV prevalence and gut microbial profile in our cohort of children with SCD and compare this with matched healthy children and to ascertain if diet or pancreatic function affects these levels and see if these affects sickle cell severity.


2022 Copyright, the authors

Available for download on Thursday, December 05, 2024