Master of Science (MS)
Medical Sciences Interdepartmental Area
H. Dele Davies MD, MS, MHCM
Peter Mannon MD, MPH
Corrine Hanson PhD, RD, LMNT
Stephen Obaro MD, PhD
Fat soluble vitamins, Microbiome, Sickle Cell
Fat soluble vitamin (FSV) deficiencies are associated with worse pain in individuals with sickle cell disease (SCD). Data on the dietary and pancreatic function influence on fat soluble vitamin levels are limited. Additionally, individuals with SCD have gut dysbiosis but there are gaps in knowledge on the impact of this on severity. This thesis attempted to evaluate FSV prevalence and gut microbial profile in our cohort of children with SCD and compare this with matched healthy children and to ascertain if diet or pancreatic function affects these levels and see if these affects sickle cell severity.
Dike, Chinenye R., "The Link Between Fat Soluble Vitamin Deficiencies, Decreased Microbiota Diversity and Severity in Children with Sickle Cell Disease Followed in a Clinic in Omaha Nebraska" (2022). Theses & Dissertations. 699.
Available for download on Thursday, December 05, 2024