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Theses/Dissertations from 2015

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Effect of peripheral shell cross-linking on the efficacy of a hydrophobic vascular disrupting agent physically loaded in core-shell polymeric micelles, Rajesh Rajan Wakaskar

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Antiviral Peptide Nanocomplexes As Potential Therapeutics For The Treatment Of Infectious Diseases, Jinjin Zhang

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The targeted delivery of bone anabolic agents to improve fracture healing, Yijia Zhang

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Amyloid Proteins Structure, Dynamics, Interactions and Early Stages of Self-Assembly, Yuliang Zhang

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Development of Hypoxia Trapping Enhanced BB2R-Targeted Radiopharmaceutics for Prostate Cancer, Zhengyuan Zhou

Theses/Dissertations from 2014

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Development of EP67-based mucosal vaccines against cytomegalovirus infection, Bala Vamsi Krishna Karuturi

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Misfolding and aggregation of yeast prion protein SUP35P using atomic force microscopy and complementary biophysical methods, Alexander M. Portillo

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Remote actuation of magnetic nanoparticles in breast cancer cells, Philise Nicole Williams

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Development of macromolecular prodrugs for improved treatment of lupus nephritis, Fang Yuan

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The structure and function of caveolin proteins, Yanli Zhang

Theses/Dissertations from 2013

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Cholesterol-siRNA polyplexes of polycation-polyethylene glycol diblock copolymers for cancer therapy, Vishakha Vilas Ambardekar

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Bile acids as biomarkers for hepatobiliary diseases, Sai Praneeth Reddy Bathena

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Multi-functional antioxidants targeting neurodegenerative diseases, Hiroyoshi Kawada

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Development of a theranostic system for aseptic implant loosening, Ke Ren

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Poly(2-oxazoline) as a polymer carrier for cellular and brain delivery of therapeutic proteins and fullerene, Jing Tong

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Amphiphilic block copolymers for enhancing doxorubicin and doxil based chemotherapy by sensitizing cancer stem cells and promoting drug release within tumors, Yi Zhao

Theses/Dissertations from 2012

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Mechanistic study of pluronic interactions in multidrug resistant and tumor initiating cells, Daria Y. Alakhova

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Population pharmacokinetic analysis of anti-retroviral therapies, Gautam Baheti

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Dentotropic technologies for the prevention and treatment of dental plaque related diseases, Fu Chen

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Computational studies and inhibitors design of P13Kalpha, Dima Sabbah

Theses/Dissertations from 2011

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AFM characterization of protein-DNA interactions, Jamie Gilmore

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Polymer micelles with cross-linked ionic cores for delivery of platinum anticancer agents, Hardeep Singh Oberoi

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Development of multi-functional antioxidants for use in cataract and age-related macular degeneration, James Michael Randazzo

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Retinal delivery of steroidal and non-steroidal drugs for the treatment of back of the eye disorders, Ashish Thakur

Theses/Dissertations from 2010

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Bis-styrylbenzenes and their potential in alzheimer's disease, Daniel P. Flaherty

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Design and synthesis of a click polyrotaxane for the improved treatment of musculoskeletal diseases, Christopher Donald Hein

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Polymer micelles with cross-linked ionic cores for delivery of doxorubicin, Jung Oh Kim

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Unusual dna intramolecular secondary structures : unfolding thermodynamics and their application in controlling gene expression, Hui-Ting Lee

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Protein modification by pluronic block copolymer for brain delivery, Xiang Yi

Theses/Dissertations from 2009

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Pluronic block copolymers for non-viral gene therapy, Zagit Z. Gaymalov

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Atomic force microscopy characterization of misfolding and aggregation of yeast prion protein SUP35P, Alexander M. Portillo

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Tat-conjugated nanoparticles for the cns delivery of anti-hiv drugs, Kavitha S. Rao

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Mechanism (s) of encocytosis for cellular entry of novel nanomaterials, Gaurav Sahay

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The interaction of DNA polymerases with N3-Methyladenine and related analogs, Sam Settles

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Targeted drug delivery for the management of choroidal neovascularization, Swita R. Singh

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Deslorelin functionalized nanosystems for anti-cancer drug and gene delivery, Sneha Sundaram

Theses/Dissertations from 2008

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Effect of size of PLGA and chitosan-PLGA particles on the cellular association, cytotoxicity, and anti-tumor efficacy of Paclitaxel, Sudhir S. Chakravarthi

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Transscleral drug delivery : role of physiological, physico-chemical and pathological factors in delivering drugs to the posterior segment of eye, Narayan PS Cheruvu

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Thermodynamic characterization of the folding and interactions of G-Quadruplexes, Christopher Michael Olsen

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Nanoparticle-cell interactions, intracellular trafficking, and protein therapy for restenosis, Jaspreet K. Vasir

Theses/Dissertations from 2007

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Periocular particulate systems: disposition, safety and efficacy, Aniruddha C. Amrite

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Pharmacokinetic modeling of therapeutic antibodies, Jasmine P. Davda

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Biophysical characterization of DNA duplexes containing modified nucleotides that influence DNA hydration and cation organization, Manjori Ganguly

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Supercritical fluid technology for fabrication of gene delivery nanoparticles, Aaron S. Mayo

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Effects of pluronic block copolymers on gene delivery and expression, Srikanth Sriadibhatla

Theses/Dissertations from 2006

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Cross Linked Polymer Micelles for Cisplatin Delivery, Satya S. Bontha

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Environmentally responsive materials based on block-, graft-, and cross-linked copolymers for pharmaceutical applications, Kyung T. Oh

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Physiological and pathophysiological modulation of blood-brain barrier integrity, Sanjot D. Savant

Theses/Dissertations from 2005

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Physiologically based pharmacotkinetic (PBPK) modeling of anticancer drugs, Jing Li

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Energetics, ion and water binding in the unfolding of DNA : nearest neighbor contributions and incorporation of bulges, mismatches, cationic chains and base-triplet stacks, Ronald Angel Shikiya

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Study of self-assembly and environmental response properties of block ionomer complexes, Sergey V. Solomatin

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Tumor necrosis factor alpha (TNF) induced alterations in brain microvessel endothelial cell (BMEC) permeability, William J. Trickler

Theses/Dissertations from 2004

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Retinal delivery of drugs capable of inhibiting VEGF expression, Surya P. Ayalasomayajula

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Functional assays for drug efflux transporters in the blood-brain barrier, Corbin J. Bachmeier

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Central nervous system distribution of novel antitumor agents, pemetrexed and STI-571: role of efflux transport systems, Haiqing Dai

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Respiratory delivery of deslorelin, a peptide drug, Kavitha Koushik

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Mechanism and efficacy of nanoparticle-mediated WT-P53 gene therapy in breast cancer model, Swayam Prabha

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Effect of pluronic P85 on transgene expression in skeletal muscle and potential use of this agent for antitumor DNA vaccination, Jian Zhu

Theses/Dissertations from 2003

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Lung delivery of budesonide and its efficacy in a tumour model, Nagesh Bandi

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Effect of size of paclitaxel-PLGA particles on release, cell-association, and cytotoxicity in 4T1 cells, Sinjan De

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Biodegradable nanoparticles : formulation, cellular mechanism and application for restenosis, Jayanth Panyam

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Innovative approaches to pharmacokinetic model selection, Steven P. Riley

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Sequence specific DNA minor groove alkylating agents and their biological activity, Dharini Shah

Theses/Dissertations from 2002

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Retinal delivery of an aldose reductase inhibitor and a VEGF antisense oligonucleotide, Jithan V. Aukunuru

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The In vitro and in vivo transport of the novel lipophilic, silicon-containing, camptothecin, DB-67, Christine M. Brandquist

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Studies of alginate particulate formulations prepared by ionotropic gelation containing small molecules or deslorelin, Preeti Dochibhotla

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Block ionomer complexes with retinoic acid for drug delivery, Andrew John Nehls

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Thermodynamics for the unfolding of non-canonical nucleic acids : bent duplexes, okazaki fragments and DNA triplexes, Ana Maria Soto

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Transport, pharmacokinetics and ocular delivery of N-4-[(Benzoylamino)phenylsulfonyl]glycine : an aldose reductase inhibitor, Gangadhar Sunkara

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Characterization of multidrug resistance-associated protein (MRP) homologues in the blood-brain barrier (BBB), Yan Zhang

Theses/Dissertations from 2001

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Oxidation of 4-hydroxycatechol estrogens to their genotoxic quinones by transition metal ions, cytochrome P450 with linoleic acid hydroperoxide as cofactor, and prostaglandin H synthase-1, Lisa Zaddock Crandall

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Estimation of population pharmacokinetic parameters in the presence of noncompliance, Song Mu

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Organic anion transport in the central nervous system : a study of fluorescein cns distributional kinetics, Haiying Sun

Theses/Dissertations from 2000

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Synthesis and characterization of chemically modified oligonucleotides and sequence specific DNA alkylating agents, Prasad Dande

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Nanospheres for the sustained delivery of vascular endothelial growth factor in angiogenesis therapy, Jasmine P. Davda

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The Design and development of a biodegradable polylactide reservoir for controlled, zero-order drug delivery, Sriramakamal Jonnalagadda

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Synthesis, stability, and anticancer activities of FdUMP prodrug FdUMP[10] and its folic acid, cholesterol derivatives, Jinqian Liu

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Allyl sulfide inhibition of the metabolism of methylamylnitrosamine, Chantey R. Morris

Theses/Dissertations from 1999

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Regulation of phosphatase activity of calcineurin, Bo Feng

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Characterization of tumor necrosis factor-alpha (TNF-alpha) induced permeability effects in brain microvessel endothelial cells, Karen S. Mark

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Examination of BCECF-AM as a probe for druge efflux transporters, Aimee Beth Schreiner

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Role of albumin in tolbutamide metabolism by liver microsomes, Bing Wang

Theses/Dissertations from 1998

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Aromatic hydrocarbon radical cations and their reactions with nucleosides and DNA. Metabolic activation of 6-methylbenzo[a]pyrene, Aaron A. Hanson

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Modified thymines used in potential antisense therapies, Lauren E. Heystek

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In vitro and in vivo properties of an in situ forming gel for the parenteral delivery of macromolecular drugs, Rajashree Joshi

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An in situ-gelling system for the extended delivery of ophthalmic drugs, Shilpa Kaushik

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In vitro pharmacokinetics and pharmacodynamics of BCNU, Hiroko Ueda

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Chloroquine, hematin and malaria, Sudha Rani Vippagunta

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The effect of inhibition of P-glycoprotein on drug distribution across the blood-brain barrier : an in vivo study using microdialysis in the freely-moving rat model, Qin Wang

Theses/Dissertations from 1997

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Fluconazole distributional kinetics to the central nervous system using microdialysis in the freely-moving rat model, Hua Yang

Theses/Dissertations from 1996

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Feasibility and in vitro characterization of an injectable, in situ gel-forming system for enzyme replacement therapy, Sandeep Kumar

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Evaluation of topical delivery properties of apigenin in different vehicles and the implications in skin cancer prevention, Boyong Li

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The effects of 5-fluorouracil incorporation on the structure and stability of nucleic acids, Parag V. Sahasrabudhe

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Assessment and comparison of the renal disposition of cyclosporine A and cyclosporine G in the isolated perfused rat kidnay, Michelle Lynne Strong

Theses/Dissertations from 1995

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The relationship between dimethylnitrosamine metabolism and DNA methylation in isolated rat hepatocytes, Lance Encell

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Design and characterization of deferoxamine derivatives with improved biomembrane permeability, Peter M. Ihnat

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The use of chemical reagents to sequence DNA and probe DNA structure, Gangning Liang

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The effects of 5-fluorouridine incorporation on the structure of the 5'stem-lopf from U4-snRNA, Junqu Sun

Theses/Dissertations from 1994

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Development and evaluation of biodegradable films for the controlled release of tetracycline HC1 into intracrevicular fluid, Rajesh Kumar Agarwal

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Physicochemical aspects of dissolution and controlled release of mesalamine and structurally related compounds from carbopol gels, Donna L. French