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Theses/Dissertations from 2024

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The Interactions of Centromeric Nucleosomes Elucidated by Atomic Force Microscopy, Shaun Filliaux

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Assessment of In-Vitro and In-Vivo Pre-Clinical Pharmacokinetics of EPZ015666; A Novel Small molecule for medulloblastoma treatment, Pratiksha U. Kshirsagar

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Pharmacodynamic Effects of ZSJ-0228 on Complement Protein Deposition In The Kidneys of Focal Segmental Glomerulosclerosis-Afflicted Mice., Braeden Pinkerton

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Synthesis and Characterization of Zoledronic Acid Prodrugs: A Potential Therapeutic for Enhanced Drug Delivery and Targeted Treatment, Shweta Wani

Theses/Dissertations from 2023

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Phenotypic and Target-based Drug Discovery, Angelica Veronica Carmona

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Creation of TatDE rLNPs for the Excision of Integrated HIV-1 Proviral DNA, Mahmudul Hasan

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Targeting Metabolic Switches and DNA Damage Repair for the Treatment of Human Diseases, Rasangi Chathurika Kankanam Pathirage

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Paper-based Ratiometric Sensor Array for Pathogenic Bacterial Species Identification, Aayushi Laliwala

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Design, Synthesis, and Evaluation of Novel Peptidomimetics as Neurolysin Activators for the Treatment of Ischemic Stroke., Md. Shafikur Rahman

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Targeted Therapies for Improving the Treatment of Sonic Hedgehog and MYC Driven Medulloblastoma, Bharti Sethi

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Intramuscular Administration of the Host-Derived Immunostimulant CPDI-02 Increases Protection of Outbred Mice and Piglets Against Dermal MRSA Infection in a Curative Setting and is Well Tolerated After Repeated Administration, Jason P. Stewart

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Design and Synthesis of Small Molecule Drugs for CNS Disorders, Kirsten T. Tolentino

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Dynamics of Site Search Process and Formation of Synaptosome Assembly Characterized by Single Molecule Approaches, Sridhar Vemulapalli

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Design, Synthesis, and Characterization of Peptide Amphiphile Biomaterials, Huihua Xing

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Polycationic Nanoparticle Delivery of Nucleic Acids for the Treatment of Fibrosis in Alcohol-Associated Liver Diseases, Chuhan Zhang

Theses/Dissertations from 2022

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Biologically-Inspired Nanoparticles For Oncology Applications, Aishwarya Bapat

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Targeted Therpeutics for Prostate Cancer, Behind the Scenes of PSMA & Cysteine Protease Trapping Mechanism, Alireza Basiri

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Polymeric Nanocarriers for Delivery of Small Molecules Inhibiting Tubulin Polymerization for the Treatment of Pancreatic Cancer and Lung Metastatic Melanoma, Rajan Sharma Bhattarai

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The Development of Thermoresponsive Hydrogel-Based Drug Delivery Systems for the Treatment of Musculoskeletal Diseases, Ningrong Chen

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Development of Perfluorocarbon Nanoemulsions for Delivery of Therapeutic Nucleic Acids, Ling Ding

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Structural and Biochemical Studies of Three Enzymes Involved in Amino Acid Metabolism to Develop Novel Drugs, Yahani Pankaja Jayasinghe Arachchige

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Structural and Inhibitory Studies on (i)Two Mycobacterium Tuberculosis Enzymes Essential for Capsular Glucan Biosynthesis and mRNA Degradation: (Ii) Hantann Virus L-Protein Endonuclease Domain, Hettiarachchige Thilina D. Jayasinghe

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Macromolecular Fluorescent Conjugates for Bioimaging Applications, Paul Lovell

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Innate Immunity in the Pathobiology and Treatment of Infectious and Neurodegenerative Diseases, Mai Mostafa

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The Development and In Vivo Immunologic Assessment of Biodegradable Microparticles Incorporating CPDI-02 and Mucosal Protein Vaccine, Jacob E. Parriott

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Applications of Population Pharmacokinetic Modeling in People Living with HIV, Michelle M. Pham

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Design, Synthesis, and Biological Investigation of Pyridine Sulfones as Anti-Chlamydia trachomatis Agents, Mohamed A. Seleem

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Dynamics of Nucleosome Assembly Characterized by Atomic Force Microscopy, Tommy Stormberg

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Development of Bioactive Polymers for Anticancer siRNA Therapy, Siyuan Tang

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Modulation of Immune Homeostasis in Neurodegenerative Diseases, Pravin Yeapuri

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Nanofabrication for Precision Vaccinology, Karen Zagorski

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The Development of Polymeric Dexamethasone Prodrug Nanomedicines for the Treatment of Lupus Nephritis, Zhifeng Zhao

Theses/Dissertations from 2021

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Modification and Antichlamydial Activity Evaluation on Dysregulators of Cylindrical Proteases, Jiachen Feng

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Design, Synthesis and Antineoplastic Evaluation of a Variety of Small Molecule Scaffolds, Bader Huwaimel

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Development of Once-A-Year Injectable Formulation of Cabotegravir for Prevention and Treatment of HIV Infection, Tanmay Abhay Kulkarni

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Urinary Bile Acid Indices as Prognostic Biomarkers for the Complications of Liver Diseases, Wenkuan Li

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Design, Synthesis and Evaluation of Novel Inhibitors of Type 5 and 10 17β-Hydroxysteroid Dehydrogenases, Ahmed Morsy

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Development of Macromolecular Prodrug of Sinomenine for the Treatment of Rheumatoid Arthritis, Roshni Mukundan

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Design and Synthesis of Small Molecular probes for CNS and Kidney Disorders, Swagat H. Sharma

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Structural and Inhibitory Studies of Enzymes Essential for Cell Wall and Ergothioniene Biosynthesis in Mycobacterium Tuberculosis, Thanuja D. Sudasinghe

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Development of Polymeric CXCR4 Targeting Carriers for siRNA Delivery to Treat Acute Kidney Injury, Weimin Tang

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Dynamics of Protein-DNA Interactions Characterized by Atomic Force Microscopy, Yaqing Wang

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Delivery of SiRNA with Drugs Targeting Polyamine Metabolism as Combinational Cancer Treatment, Ao Yu

Theses/Dissertations from 2020

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Urinary Bile Acid Indices as Diagnostic and Prognosic Biomarkers for Liver Diseases, Jawaher Alamoudi

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Development of an LC-ESI-MS/MS method for determination of a novel Pyrrolomycin (MP-1) and application to pre-clinical ADME studies, Wafaa N. Aldhafiri

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Delivery for Hydrophobic Drugs for Treating Pancreatic Cancer, Saud Almawash

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Polymeric Drug Delivery Systems for Cancer Therapy and Radionuclide Decorporation, Sameer A. Alshehri

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Ocular, Neural, and Cellular Biodistribution of Multifunctional Antioxidants, Damian Daszynski

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Development of CXCR4-inhibiting RNA delivery vectors for the treatment of metastatic pancreatic cancer, Yu Hang

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Next Generation Aryl Hydantoins as Antischistosomal Agents, Derek A. Leas

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Smart Delivery of Genes and Drugs for Treatment of Cancer, Feng Lin

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Rilpivirine-Associated Aggregation-Induced Emission Enables Cell-Based Nanoparticle Tracking, Insiya Mukadam

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Anti-MUC4β antibodies as a novel therapeutic modality for the treatment of pancreatic cancer, Catherine Orzechowski

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Development of Hyaluronic Acid-Derived Macromolecular Agents for Multimodal Imaging Probes and Nanomedicine, William M. Payne

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Long-Acting Nanoformulated Antivirals for the Treatment and Prevention of HIV-1 and HBV infections, Dhruvkumar M. Soni Dr.

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Ligand-Installed Polymeric Nanocarriers for Combination Chemotherapy, Xinyuan Xi

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Development of Cholesterol Modified RNAi Polyplexes for Breast Cancer Therapy, Zhen Ye

Theses/Dissertations from 2019

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Computational Studies and Design of PPARγ and GLUT1 Inhibitors, Suliman Almahmoud

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Development of Local Drug Delivery Systems for Periodontal Disease, Yosif Hassan Almoshari

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Identification of more potent and efficacious analogs of the novel host-derived immunostimulant EP67, Abdul Alshammari

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Engineering Hyaluronic Acid for Biomedical Applications, Deep S. Bhattacharya

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Development of Long-acting Nanoformulated Abacavir ProTides, Zhiyi Lin and Howard E. Gendelmant

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Charge-Based Optimization of Neurotensin for Neurotensin-Receptor-1 Targeting Utilizing a One-Bead One-Compound Peptide Library Approach, Trey Neeley

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Delivery of Small Molecule and RNA Using Synthetic Polymeric Micelles and Multifunctional Exosomes for the Treatment of Type 1 Diabetes, Yang Peng

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The Development of Hyaluronan-Based Contract Agents for the Intraoperative Detection of Pancreatic Tumors, Bowen Qi

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Polymeric Chloroquine: Modifying an Old Drug to Make It a Little Sweeter, Richard Sleightholm

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Macromolecular Prodrug for the Treatment of Ulcerative Colitis, Yuanyuan Sun

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Development of Approaches of Tumor Trapping Enhanced BB2R-Targeted Radiopharmaceuticals for Prostate Cancer, Wenting Zhang

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Development of Macromolecular Prodrug Conjugates for the Treatment of Inflammatory Diseases, Gang Zhao

Theses/Dissertations from 2018

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Development of Polymeric Carriers for the Treatment of Acute Kidney Injury, Yi Chen

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Molecular Mechanism of Early Amyloid Self-Assembly Revealed by Computational Modeling, Mohtadin Hashemi

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Development of Novel Therapies for the Treatment of Inflammatory Bowel Disease, Shrey Kanvinde

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Developing of Micellar Drug Carriers for the Treatment of Breast Cancer Bone Metastasis, Tong Liu

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The Opposing Roles of GluN2C and GluN2D NMDA Receptor Subunits in Modulating Neuronal Oscillations, Zhihao Mao

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Development of Glucocorticoid Prodrug for the Treatment of Lupus Nephritis, Xiaobei Wang

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Development of Macromolecular Prodrugs for the Treatment of Chronic Inflammatory Pain, Laura Weber

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Development of Macromolecular Prodrug Conjugates for the Diagnosis and Treatment of Musculoskeletal Diseases, Xin Wei

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Delivery of MicroRNA with CXCR4-Targeted Nanoparticles in Metastatic Cancer Treatment, Ying Xie

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Polymeric Nanocarriers Delivering Anticancer Agents for the Treatment of Chemoresistant Prostate Cancer and Lung Metastatic Melanoma, Ruinan Yang

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Development of Chloroquine-containing HPMA Copolymers for Drug Delivery, Fei Yu

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Next Generation of Translational Long-Acting Cabotegravir, Tian Zhou

Theses/Dissertations from 2017

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Development of CXCR4 Inhibitors for Topical Treatment of Psoriasis, Suthida Boonsith

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Development of Neurotensin-Based Radiopharmaceuticals For Neurotensin-Receptor-1-Positive Tumors Targeting, Yinnong Jia

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Targeted Delivery of Drug Combinations Via Nanocarriers for Cancer Treatment, Kruti Soni

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Development of C5AR-Targeted Nanoparticles for Delivery of Vaccines, Shailendra Bharadwaj Tallapaka Venkata Sesha

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In-Vitro and In-Vivo Models of Bile Acid Metabolism and Transport, Rhishikesh Thakare

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Delivery of small molecule and RNA for the treatment of type 1 diabetes and prostate cancer, Di Wen

Theses/Dissertations from 2016

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Long-Acting Antiretroviral Nanoformulation Development and Subcellular Trafficking, Dongwei Guo

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Chemosensitization Effect of SP1017 on Multiple Myeloma, Hangting Hu

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Polymeric Nanocarriers for Delivery of Small Molecules and miRNAs for the Treatment of Liver Fibrosis and Pancreatic Cancer, Virender Kumar

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Synthesis and Development of Long-Acting Abacavir Prodrug Nanoformulations, Dhirender Singh

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Stability and Kinetics of DNA Pseudoknots: Formation of T∗A•T Base-Triplets and Their Targeting Reactions, Calliste Steffensmeier

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Block Copolymer Based Magnetic Nanoclusters for Cancer-Theranostics: Synthesis, Characterization and In Vitro Evaluation, Hemant M. Vishwasrao

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Design, Synthesis, and Evaluation of Aryl Hydantoins and Ureas as Antischistosomal Agents, Chunkai Wang

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Development of CXCR4-Inhibiting Nanoparticles for the Treatment of Metastatic Cancer, Yan Wang

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The Functions of the CID and lRG Operons in S. Aureus Programmed Cell Death, Xinyan Zhang

Theses/Dissertations from 2015

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Biodegradable Hybrid Nanogels for Combination Chemotherapy, Swapnil Desale

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Polymeric Nanocarriers for Treatment of Melanoma and Genetically Modified Mesenchymal Stem Cells to Improve Outcome of Islet Transplantation, Vaibhav Mundra

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Development of Polymer Peptide Conjugates for Enhanced Pancreatic Cancer Imaging, Wen Shi

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Effect of peripheral shell cross-linking on the efficacy of a hydrophobic vascular disrupting agent physically loaded in core-shell polymeric micelles, Rajesh Rajan Wakaskar