DigitalCommons@UNMC

Title

TDP-43 Phase Separation Does Not Likely Regulate LPS-Induced Neuroinflammation

Author

Marshall Dawkins, University of Nebraska Medical CenterFollow
Justin Dunn, University of Nebraska Medical CenterFollow
Ju Gao, University of Nebraska Medical CenterFollow
Ariele Peters, University of Nebraska Medical CenterFollow
Xiaojia Ren, University of Nebraska Medical CenterFollow
Devanshi Shukla, University of Nebraska Medical CenterFollow
Luwen Wang, University of Nebraska Medical CenterFollow
Xinglong Wang, University of Nebraska Medical CenterFollow

Files

Presentation date

2021

College, Institute, or Department

Pharmacology and Experimental Neuroscience

Research Mentor

Xinglong Wang

Abstract

Immunohistochemistry (IHC) was performed to assess whether Transactive response Deoxyribonucleic acid binding Protein 43 (TDP-43) liquid-liquid phase separation (LLPS) regulates lipopolysaccaride (LPS)-induced neuroinflammation. Quantification and intensity results of glia cells and cytokines indicate that TDP-43 LLPS does not likely regulate LPS-induced neuroinflammation.

Keywords

TDP-43, phase separation

Recommended Citation

Dawkins, Marshall; Dunn, Justin; Gao, Ju; Peters, Ariele; Ren, Xiaojia; Shukla, Devanshi; Wang, Luwen; and Wang, Xinglong, "TDP-43 Phase Separation Does Not Likely Regulate LPS-Induced Neuroinflammation" (2021). Posters: 2021 Summer Undergraduate Research Program. 57.
https://digitalcommons.unmc.edu/surp2021/57