Mitovesicle Proteomic Signatures of Social Defeat Stress in NeuroHIV

Author

• Rakan Abuissa, University of Nebraska Medical CenterFollow
• Mark Bausch, Notre Dame CollegeFollow
• Micheal Ayoub, University of Nebraska Medical CenterFollow
• Dalia Moore, University of Nebraska Medical CenterFollow
• Gurudutt Pendyala, University of Nebraska Medical CenterFollow
• Sowmya V. Yelamanchili, University of Nebraska Medical CenterFollow

Files

Presentation date

Summer 8-6-2026

College, Institute, or Department

Anesthesiology

Faculty Mentor

Dr. Sowmya V. Yelamanchili

Research Mentor

Dr. Sowmya V. Yelamanchili

Abstract

Mitochondria-derived extracellular vesicles (EVs) that have recently emerged as important mediators and biomarkers of neurodegenerative diseases. Changes in their abundance and molecular cargo may serve as sensitive indicators of mitochondrial stress, dysfunction, and cellular health. This study validates the efficiency and reproducibility of our rat brain mitovesicle isolation protocol. Furthermore, it aims to elucidate how mitochondrial signaling, reflected by mitovesicle characteristics and cargo, is altered following social defeat stress and whether these effects are further exacerbated by HIV infection. These findings may provide novel insights into the role of mitochondrial dysfunction in HIV-associated neurocognitive impairment and stress-related neuropathology.

Rights

The author holds the copyright to this work and any reuse or permissions must be obtained from the author directly.

Keywords

Mitovesicles, Social Defeat, Mitochondria

Recommended Citation

Abuissa, Rakan; Bausch, Mark; Ayoub, Micheal; Moore, Dalia; Pendyala, Gurudutt; and Yelamanchili, Sowmya V., "Mitovesicle Proteomic Signatures of Social Defeat Stress in NeuroHIV" (2026). Posters: 2026 Summer Undergraduate Research Program. 2.
https://digitalcommons.unmc.edu/surp2026/2