Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

Authors

Eman A. Alraddadi, University of Manitoba
Ryan Lillico, University of Manitoba
Jonathan L. Vennerstrom, University of Nebraska Medical CenterFollow
Ted M. Lakowski, University of Manitoba
Donald W. Miller, University of Manitoba

Document Type

Article

Journal Title

Pharmaceutics

Publication Date

2018

Volume

10

Abstract

Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders. Until now, little is known about its pharmacokinetic profile. Our objective was to determine the oral bioavailability of CM and the influence of dose on oral absorption. Rats were dosed orally with low dose (10 mg/kg) or high dose (70 mg/kg)

DOI Link

10.3390/pharmaceutics10010031

ISSN

1999-4923

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Alraddadi, Eman A.; Lillico, Ryan; Vennerstrom, Jonathan L.; Lakowski, Ted M.; and Miller, Donald W., "Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth" (2018). Journal Articles: Pharmaceutical Sciences. 21.
https://digitalcommons.unmc.edu/cop_pharmsci_articles/21