Document Type
Original Report
Disciplines
Higher Education | Medicine and Health Sciences | Neoplasms | Oncology | Otolaryngology | Pathological Conditions, Signs and Symptoms
Abstract
Background: Although systemic immune-inflammation index (SII) correlates with patient survival in various solid malignancies limited information is available in the setting of oral cavity squamous cell carcinoma (OCSCC).
Methods: We retrospectively reviewed 222 patients who underwent a resection of curative intent for patients with OCSCC. SII was determined prior to surgical resection as platelet count × neutrophil count/lymphocyte count.
Results: At a median follow-up of 30.6 months, 2-year disease-free survival (DFS) and overall survival (OS) rates were 63.9% and 76.4%, respectively. A high SII (>1047) was associated with poor performance status and disease extent. A low SII was independently associated with improved DFS (HR: 0.440, pp=0.007) rates.
Conclusions: SII values at diagnosis were associated with patient performance status, disease extent at the time of diagnosis, improved disease control rates, and improved patient survival.
DOI
https://doi.org/10.32873/unmc.dc.gmerj.5.1.001
Keywords
Inflammation, oral cavity, squamous cell carcinoma, SII
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Coutu, B., Christensen, D. N., Ryan, E., Bradford Bell, E., Zhen, W., , Sayed, Z. Systemic Inflammation is Associated with Disease Extent and Survival in Oral Cavity Squamous Cell Carcinoma. Graduate Medical Education Research Journal. 2023 Jun 30; 5(1).
https://digitalcommons.unmc.edu/gmerj/vol5/iss1/1
Included in
Higher Education Commons, Neoplasms Commons, Oncology Commons, Otolaryngology Commons, Pathological Conditions, Signs and Symptoms Commons
