Document Type

Original Report


Higher Education | Medicine and Health Sciences | Neoplasms | Oncology | Otolaryngology | Pathological Conditions, Signs and Symptoms


Background: Although systemic immune-inflammation index (SII) correlates with patient survival in various solid malignancies limited information is available in the setting of oral cavity squamous cell carcinoma (OCSCC).

Methods: We retrospectively reviewed 222 patients who underwent a resection of curative intent for patients with OCSCC. SII was determined prior to surgical resection as platelet count × neutrophil count/lymphocyte count.

Results: At a median follow-up of 30.6 months, 2-year disease-free survival (DFS) and overall survival (OS) rates were 63.9% and 76.4%, respectively. A high SII (>1047) was associated with poor performance status and disease extent. A low SII was independently associated with improved DFS (HR: 0.440, pp=0.007) rates.

Conclusions: SII values at diagnosis were associated with patient performance status, disease extent at the time of diagnosis, improved disease control rates, and improved patient survival.




Inflammation, oral cavity, squamous cell carcinoma, SII

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.



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