Document Type
Case Report
Disciplines
Higher Education | Medicine and Health Sciences
Abstract
Background. Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder characterized by generalized lymphadenopathy, systemic inflammatory symptoms, and distinctive histopathologic findings. HHV-8-associated MCD is typically observed in patients with human immunodeficiency virus (HIV) infection or other states of profound immunosuppression. In contrast, HHV-8-associated disease in immunocompetent individuals is uncommon and associated with higher mortality rates.
Case. This is a case of a patient who presented with progressive fatigue, weakness, anorexia, and a chronic cough for four months following a trip to Mexico. Initial workup revealed anemia and thrombocytopenia, negative HIV status, and prominent bilateral axillary and mediastinal lymphadenopathy, which was later confirmed by pathology to represent HHV-8-associated multicentric Castleman disease (MCD) with concurrent Kaposi sarcoma.
Conclusion. We highlight an unusual presentation of HHV-8-associated MCD in an immunocompetent patient, illustrating the different clinical courses for HIV positive HHV-8-associated MCD compared with HIV negative HHV-8-associated MCD, and emphasize the essential role of pathology in certain infectious disease diagnoses.
DOI
10.32873/unmc.dc.gmerj.8.2.005
Keywords
Multicentric Castleman Disease, Kaposi Sarcoma, HHV-8, KSHV
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Shad, K., Logeman, A., Van Schooneveld, T. C., , Dyer, E. Kaposi Sarcoma and HHV-8-Associated Multicentric Castleman Disease: A Case Report. Graduate Medical Education Research Journal. 2026 Oct 30; 8(2).
https://digitalcommons.unmc.edu/gmerj/vol8/iss2/5
