Symmetrical Drug-Related Intertriginous and Flexural Exanthema Induced by Cellulitis Prophylaxis

Authors

Tiffany Truong, University of Nebraska Medical CenterFollow
Jonathan H. Ryder, University of Nebraska Medical Center, Department of Internal Medicine, Division of Infectious DiseasesFollow
Erica Lee, University of Nebraska Medical CenterFollow
Clayton Mowrer, University of Nebraska Medical Center, Division of Infectious DiseasesFollow
Ashley Wysong, University of Nebraska Medical CenterFollow
Jasmine R. Marcelin, University of Nebraska Medical CenterFollow

ORCID (Optional)

https://orcid.org/0000-0002-5565-4445

Document Type

Case Report

Disciplines

Allergy and Immunology | Dermatology | Higher Education | Infectious Disease | Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Abstract

Penicillin VK and hydroxyzine are typically well-tolerated antipruritic agents that are indicated in the prophylaxis of cellulitis. We herein report a case of a unique rash occurring during penicillin VK and hydroxyzine treatment in combination with the ingestion of cashews.

A 77-year-old male presented with new onset rash. Eleven days after the administration of penicillin VK and hydroxyzine for cellulitis prophylaxis, he developed a symmetric, erythematous, scaling rash on his buttocks and perineal region with associated pruritus and bleeding without fevers, chills, adenopathy, night sweats, or any other symptoms. He was diagnosed with symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) secondary to systemic treatment, an adverse drug reaction that presents as an erythematous rash involving the skin folds. The condition is also known as “baboon syndrome,” as it predominately affects the buttocks. A good outcome was achieved due to a thorough history and physical, timely diagnosis, and cessation of the offending agents.

DOI

10.32873/unmc.dc.gmerj.3.2.003

Keywords

drug rash, Symmetrical Drug-Related Intertriginous and Flexural Exanthema, SDRIFE, Baboon Syndrome, adverse drug reaction, polypharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Recommended Citation

Truong, T., Ryder, J. H., Lee, E., Mowrer, C., Wysong, A., , Marcelin, J. R. Symmetrical Drug-Related Intertriginous and Flexural Exanthema Induced by Cellulitis Prophylaxis. Graduate Medical Education Research Journal. 2021 Dec 20; 3(2).
https://digitalcommons.unmc.edu/gmerj/vol3/iss2/10