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Theses & Dissertations

Theses/Dissertations from 2023 2023

Understanding the Compositional and Contextual Factors Influencing Maternal Health Experiences and Outcomes, Tambudzai P. Ndashe

'The Very Structure of Opportunities Has Collapsed': How Taxation Policies Enhance, Decay, and Otherwise Affect the Distribution of Health & Health Services in the United States, Valerie Pacino

Applications of the RE-AIM Framework in Health Promotion, Emiliane L. Pereira

Design, Synthesis, and Evaluation of Novel Peptidomimetics as Neurolysin Activators for the Treatment of Ischemic Stroke., Md. Shafikur Rahman

SAMD14 Mechanisms in Stress Erythropoiesis, Suhita Ray

Synergetic Signaling Between the Chlamydia Secreted Effectors TarP and TmeA Regulates Actin Kinetics and Efficient Entry, Matthew Romero

A Community-Based Participatory Research Approach to Addressing Pediatric Asthma Disparities in Douglas County, Nebraska, Aislinn Rookwood

Investigating Plasmodial Proteostasis Mechanisms to Counter Artemisinin Resistance, Melissa Rosenthal

Understanding the Effect of Chikungunya Virus Infection on Bone Homeostasis, Enakshi Roy

Oxidative Damage together with Post-Occlusive Re-Oxygenation Kinetics, in Calf Muscle, Implicate Microvessels in the Myopathy of Peripheral Artery Disease, Molly Schieber

Towards a Mode of Action for the Anti-Schistosomal Aryl Hydantoins, Thomas Schulze

Investigating and Targeting Iron Metabolism in Pseudomonas Aeruginosa and Klebsiella Pneumoniae, Zachary Scott

Targeted Therapies for Improving the Treatment of Sonic Hedgehog and MYC Driven Medulloblastoma, Bharti Sethi

A Multiple Methods Study to Describe the Manifestation of Burnout of Nebraska Physical Therapists, Nicole M. Sleddens

Inter-Rater Reliability of Statistics Based on Reconstructed Individual Patient Data from Published Kaplan-Meier Curves, Megan E. Smith

Understanding Healthcare Worker Experiences and Personal Protective Equipment (PPE)-Related Skin Reactions/Injuries During the COVID-19 Pandemic: A Mixed Methods Approach, Susan Solmos

Variations in Source and Pattern of Arterial Supply to the Trigeminal Ganglion with Clinical Relevance, William S. Srinivasan

Intramuscular Administration of the Host-Derived Immunostimulant CPDI-02 Increases Protection of Outbred Mice and Piglets Against Dermal MRSA Infection in a Curative Setting and is Well Tolerated After Repeated Administration, Jason P. Stewart

Design and Synthesis of Small Molecule Drugs for CNS Disorders, Kirsten T. Tolentino

Overcoming Resistance Mechanisms to CDK4/6 Inhibitor Treatment Using CDK6-Selective PROTAC, Sarah Truong

Evaluating the Impact of Routine Enteral Iron Fortification on Gastrointestinal Dysbiosis in Premature Infants, Matthew Van Ormer

Dynamics of Site Search Process and Formation of Synaptosome Assembly Characterized by Single Molecule Approaches, Sridhar Vemulapalli

An Exploration of Policies, Equity, and Emerging Threats to the Traffic Safety Environment in the U.S., Sachi Verma

Feasibility of a Laboratory Model for Evaluating the Use of an Alternative Response Option in Mitigating Caregiver Treatment Integrity Errors, Jessie K. Weber

A Critical Assessment Of The Role Of ClpXP-Mediated Proteolysis In The Development and Differentiation Of Chlamydia trachomatis, Nicholas A. Wood

Statistical Methods for Semi-Competing and Competing Risks Data with Missing Event Types, Ruiqian Wu

Design, Synthesis, and Characterization of Peptide Amphiphile Biomaterials, Huihua Xing

Polycationic Nanoparticle Delivery of Nucleic Acids for the Treatment of Fibrosis in Alcohol-Associated Liver Diseases, Chuhan Zhang

Cardiac Vagal Dysfunction and Ventricular Arrhythmogenesis in Type 2 Diabetes Mellitus After Myocardial Infarction, Dongze Zhang

Theses/Dissertations from 2022 2022

Metoprolol Disrupts Sterol Biosynthesis through Inhibition of 7-Dehydrocholesterol Reductase (DHCR7), Luke B. Allen

Facilitating the Emergence of Intraverbal-Tacts in Autistic Children Via Joint Control, Michael Aragon

Transcranial Direct Current Stimulation of Frontal/Occipital Cortices Modulates Neural Correlates of Cognition in Healthy Young Adults, Yasra Arif

Metagenome-Wide Associations and Metabolic Modeling to Predict the Biomarkers for Colorectal Cancer, Nagavardhini Avuthu

Biologically-Inspired Nanoparticles For Oncology Applications, Aishwarya Bapat

Targeted Therpeutics for Prostate Cancer, Behind the Scenes of PSMA & Cysteine Protease Trapping Mechanism, Alireza Basiri

Astrocytic Contribution to Sensory Hypersensitivity in a Mouse Model of Fragile X Syndrome, Lara E. Bergdolt

Aberrant Age-Related Alterations in Spontaneous Cortical Activity in Participants with Cerebral Palsy, Hannah Bergwell

Exploring the Influence of Contextual Factors and the Caregiving Process on Burden, Quality of Life, and Outcomes of Heart Failure (HF) Dyads After a Hospital Discharge Guided by the Individual and Family Self-Management Theory (IFSMT): A Mixed Method Study, Tamara Bernard

Polymeric Nanocarriers for Delivery of Small Molecules Inhibiting Tubulin Polymerization for the Treatment of Pancreatic Cancer and Lung Metastatic Melanoma, Rajan Sharma Bhattarai

Grip Characterization of Protective Gloves, Doris Burns

A Cell Culture Model to Study Tobacco Associated Oral Cancer Progression and Treatment Resistance, Amanda Busch

The State of Oral Health in People with Disabilities and the Impact of Family-Centered Care on the Oral Health of Children with Special Health Care Needs, Bedant Chakraborty

Modulating Cardiac Remodeling After Myocardial Infarction, Upendra Chalise

The Development of Thermoresponsive Hydrogel-Based Drug Delivery Systems for the Treatment of Musculoskeletal Diseases, Ningrong Chen

Omics Analysis in Cancer and Development, Emalie J. Clement

Leukocyte Subsets in the Peripheral Blood and Spleen of Gastrointestinal Cancer Patients, Kathryn E. Cole

Roles of C-Terminal Domain of DNA Polymerase ζ Catalytic Subunit, Rev3, in Translesion Dna Synthesis and Origin of Mutations in Yeast, Jian Cui

Mechanisms of Sorting and Fission at the Endosomes, Kanika Dhawan

The Link Between Fat Soluble Vitamin Deficiencies, Decreased Microbiota Diversity and Severity in Children with Sickle Cell Disease Followed in a Clinic in Omaha Nebraska, Chinenye R. Dike

Development of Perfluorocarbon Nanoemulsions for Delivery of Therapeutic Nucleic Acids, Ling Ding

Linking spinal cord circuits with upper limb sensorimotor control in adults with cerebral palsy, Saihari Dukkipati

Evaluation of Awareness, Knowledge, and Preventive Intervention of Nonalcoholic Fatty Liver Disease Among Chinese Young Adults, Yi Du

Psychological Trauma Alters T-lymphocyte Inflammation and Redox Through Sympathetic Mechanisms, Safwan K. Elkhatib

Teaching Children with Autism Spectrum Disorder Self-Protection Skills in Response to Bullying Situations, Maya J. Fallon

Feasibility and Efficacy of Bisphosphonate Use for the Prevention of Bone and Muscle Loss, Laura E. Flores

Role of E3 Ubiquitin Ligase UBR5 in B Cell Development and Mantle Cell Lymphoma, Tyler J. Gilbreath

A systematic literature review of the prevalence, distribution, exposure, and human health risks of tire microplastics and the contribution of their physicochemically diverse properties, Luke Glastad

Investigating the Role of Splenic Macrophages in Pancreatic Cancer, Daisy V. Gonzalez

ERα as a Modulator of the Sle1b Lupus Susceptibility Locus and B Cell Receptor Signaling, Jared H. Graham

Investigation of Cumulative Genetic Risk and CC16 in Adult Asthma and COPD Populations, Kelli C. Gribben

Characterizing a MUC4-Based Nanovaccine and Enhancing its Efficacy by Targeting the Endothelin Axis, Mansi Gulati

Prenatal and Pregnancy Loss Evaluation by Noninvasive Screening and Diagnostic Genetic Testing, Abigail Haggerty

Extracellular Mechanotransduction in Marfan Syndrome: An Equivalence Principle, Stephen Haller

Frailty and Neurocognition in Prostate Cancer, Lindsey Hanson

Regulation of Pancreatic Cancer Progression by Micronutrients, Chunbo He

Neuropilin-2 in Advanced Prostate Cancer and its Targeting with Novel Small Molecule Inhibitors, Ridwan Islam

Structural and Biochemical Studies of Three Enzymes Involved in Amino Acid Metabolism to Develop Novel Drugs, Yahani Pankaja Jayasinghe Arachchige

Structural and Inhibitory Studies on (i)Two Mycobacterium Tuberculosis Enzymes Essential for Capsular Glucan Biosynthesis and mRNA Degradation: (Ii) Hantann Virus L-Protein Endonuclease Domain, Hettiarachchige Thilina D. Jayasinghe

An Analysis of the Genetic and Environmental Mechanisms behind Aortic Aneurysm Development and Inhibition, Kathryn E. Jespersen

Aerosols in Orthodontics: Characterization of Particle Size and Travel Distance, Donte Jochum-Nesbitt

Strengthening Capacity for Clinical and Translational Science: A Multi-Method Assessment of Research Capacity Development in a Regional Clinical and Translational Research Network, LaKaija Johnson

Gut Commensals Modulate SIV/SHIV Pathogenesis and Therapeutics, Samuel Johnson

Novel Molecular Mechanisms of C-Terminal Eps15 Homology Domain (EHD) Proteins in Endocytic Trafficking and Primary Ciliogenesis, Tyler M. Jones

Determining the Role of miR-133a in the Diabetic Heart, Tyler Kambis

Polymeric Chloroquine in Metastatic Pancreatic Cancer Therapy, Rubayat Islam Khan

Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer, Shelby M. Knoche

Returning to Life Activities after Hematopoietic Cell Transplantation in Older Adults, Thuy T. Koll

Ewing Sarcoma Transcriptome: Identification of FOXN3 as a Novel Target of EWS-FLI1, Natasha Kreiling

Mental Health Promotion, Early Identification & Treatment Services and Supports in Public K-12 School Districts: Three Case Studies to Explore Available Resources, Interventions, and Community Partnerships, Keenan Krick

Formal Caregiver Burden among Nursing Assistants in Nursing Homes: A Mixed Methods Study, Rachel Kunkle

Understanding the Perceived Risk and Biopsychosocial Impact of the COVID-19 Pandemic on People Living with HIV and Pre-Exposure Prophylaxis Users in Nebraska: A Mixed Methods Approach, Titilola O. Labisi

Increasing Young Children’s Honest Reports and Decreasing Their Transgressions, Robert K. Lehardy

The Role of Parkin in Mitochondrial DNA, Eliezer Lichter

Overcome Resistance to Drug-Induced Apoptosis in Cancer Cells, Jian Li

Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells, Cassie Liu

Novel Mechanisms of Protein Kinase C α Regulation and Function, Xinyue Li

Macromolecular Fluorescent Conjugates for Bioimaging Applications, Paul Lovell

Essential Protections for Essential Workers: Ethical Considerations for Infection Prevention and Control, Abigail E. Lowe

Underlying Mechanism of Ovarian Reserve Preservation from Gonadotoxicity, Yi Luan

Assessing the Methodology, Prevalence, and Associated Factors for Adverse Childhood Experiences (ACEs) Among Children and Adolescents in the United States, Kiara L. Lyons

CRISPR Technology as an Antiviral in dsDNA and ssRNA Viruses, Cathryn Mayes

Mobile, Biosensor Technology for Measuring Joint-Level Human Motion, Matthew McManigal

SOX2 Dosage Governs Tumor Cell Identity and Proliferation, Ethan P. Metz

The Effect of Interproximal Home Regimens of Inflammatory Biomarkers in Periodontal Maintenance Patients, Grace Moore

Exploring Host-Pathogen Interactions of the Ebola Virus Ribonucleoprotein Complex, M. Jane Morwitzer

The Role of Calprotectin in T-Lymphocyte Driven Inflammation in a Mouse Model of Psychological Trauma, Cassandra Moshfegh

Innate Immunity in the Pathobiology and Treatment of Infectious and Neurodegenerative Diseases, Mai Mostafa

Hepatocyte-Hepatic Stellate Cell Axis in Potentiation of Alcohol and HIV-Induced Liver Injury, Moses O. New-Aaron

Modulating Cellular Senescence to Improve Age-Associated Wound Healing Impairment, Upasana Niyogi

Agrichemicals (Nitrate and Atrazine) In Drinking Water and Adverse Health Outcomes in Children in Nebraska, Balkissa S. Ouattara