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Theses/Dissertations from 2025

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The Splicing Factor PTBP1 Interacts with RUNX1 and is Required for Leukemia Cell Survival, Arjun Dhir

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The Design, Synthesis and Biological Evaluation of Novel 17β-Hydroxysteroid Dehydrogenase Modulators, Louise F. Dow

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BET Protein Inhibition Relieves Myeloid-Derived Suppressor Cell-mediated Immune Suppression in Chronic Lymphocytic Leukemia, Erin M. Drengler

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Neurodegenerative Disease Mechanisms: Mitochondrial Impairment, Tau Aggregation, and Neuroinflammation as Central Drivers of Disease Progression, Luis D. Estrella

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Regulation of Chromatin Remodeling by the Post-HSA Domain of BRG1, a Subunit the BAF ATP-Dependent Chromatin Remodeling Complex, Min Sze Ewe

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Exposures, Protections, and Barriers: Advancing Understanding of Agricultural Worker Health, Alexandra A. Farfalla

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Unmasking B7-H3: A Spontaneous Small-Cell Lung Cancer Model Reveals its Dual Role in Tumor Progression and Immune Modulation, Mahek Fatima

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Understanding Stakeholder Perspectives, Medical Student Metacognition and Reflections on Learning Order Entry in the Electronic Health Record, Abbey L. Fingeret

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Schistosoma haematobium Infection in Ethiopian Children: Evaluating Praziquantel Efficacy, Nutritional Effects, and Diagnosis Using FlukeCatcher, Louis Fok

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Phosphorylation Modulates the Structure and Function of Replication Protein A, Valerie J. Fousek-Schuller

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Multi-Modal MRI for the Pre-Clinical Evaluation of HIV-Linked Changes in the Central Nervous System, Gabriel Gauthier

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A Comparison of Resurgence Following DRA and DRO, Alysa Georgopoulos

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Role of NADPH Oxidase 4 in Murine Cancer-Associated Fibroblast, Faith M. Gomez

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Navigating Nutrition Between Cultures: A Mixed Methods Study of Dietary Acculturation and Generational Status in Mexican-American Populations, Roger Gonzales

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A Comparison of Tenecteplase to Alteplase for Treatment of Acute Ischemic Stroke Using Epic Cosmos Database, Marco Gonzalez Castellon

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Role of Stabilin-1 Expressing Macrophages in Colorectal Liver Metastasis, Jampa L. Gurung

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Targeting Oxidative and Nitrosative Stress: The Role of Omega-3 Derived RvD2 and NRF2 Signaling in Hypertensive-Affected Placenta, Taija Hahka

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Cysteine-Mediated Redox Balance in Staphylococcus aureus, Abigail Hall

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Investigate the Role of TGFβ3 in Regulating IRF6 and ΔNp63 in Periderm Desquamation, Nam Ha

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Integrating Artificial Intelligence and Machine Learning with Causal Inference for Early Detection & Management of Cardiac Rejection, Roman G. Haynatzki

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The Effects of Arbitrary Reinforcers on DRO Efficiency, Reinstatement, and Reacquisition, Zeinab Hedroj

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Temporal Patterns of Ectopic Pregnancy: Using the Electronic Health Record to Illuminate a Dark Corner in Women's Health, Kirsten Hepburn

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An Extension of a Break-to-Choice Intervention with Isolated Contingency Tests for Children with Multiply Maintained Challenging Behavior, McKenna E. Herbek

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Microbiome Compositional State and Its Relation to Gut Dysbiosis in the Common Marmoset, Jordan B. Hernandez

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Presence and Performance: A Cross-Campus Analysis of Academic Performance and Course Evaluations Through the Lens of the Community of Inquiry, Shaun Horak

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Kinase Suppressor of Ras 2 Regulates Energy Balance and Tumor Initiation, Dianna H. Huisman

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Navigating Lipid Nanoparticle Design: From Microfluidic Optimization for RNA Delivery in Pancreatic Cancer to Extended-release Formulations for HIV-1 Therapy., Farhana Islam

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Optimal Two-Stage Phase II Bayesian Design, Yuanyuan Ji

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Impact of Mesenchymal Stem Cell-Derived Chemokines and Other Tumor Microenvironment Factors in Bone-Metastatic Prostate Cancer, Catherine S. Johnson

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Formative Research Study: Investigating the African American Community Perspective of Prostate Cancer by Triangulating the Association of Marital Status Within a Prostate Cancer Staging From a Population Approach, George Johnson

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Heart Failure in Rheumatoid Arthritis: Epidemiology, Determinants, and Gaps in Risk Stratification, Tate M. Johnson

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Restoring Translational Control with Novel Small Molecule Activators of PP2A in Cancer Cells, Kayla A. Jonas

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Leveraging Biomarkers to Accelerate Drug Development and Patient Care, Vineet A. Joshi

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Development of Self-Assembled Polymeric Polyplexes for MicroRNA Delivery: Toward Treatment of Alcohol-Associated Liver Disease, Marjina Akter Kalpana

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Neoadjuvant Gene Therapy with Calreticulin and R848: A Novel Approach to Pancreatic Ductal Adenocarcinoma Treatment, Ekta Kapoor

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Targeting FOXM1/Aurora Kinase B Axis Attenuates Small Cell Lung Cancer Growth, Metastasis and Chemoresistance, Md Arafat Khan

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Optimizing Small Molecule Targeted Radionuclide Therapeutics for Enhanced Tumor Retention in Ovarian and Colorectal Cancer, Sadie Klein

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Intrinsic and Extrinsic Drivers of Bioaerosol Decay: Investigating Pathogen Stability of Bacteriophage MS2, Sin Nombre Virus, and SARS-COV-2 in Simulated Environments, Elizabeth A. Klug

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Model Informed Approach to Support the Repurposing of Brompheniramine for Tumor Associated Neuroinflammation: Mechanistic Dose Prediction and Brain Exposure Assessment, Amit C. Kolhe

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Assessment of Cellular Metabolism in Disease Progression and Prevention, Sai Sundeep Kollala

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Biological Response of Abaloparatide and Alendronate on the Osteochondral Tissue of TMJ-OA, Jonjei Ku

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Assessment of Polymeric Chloroquine Formulations for Targeted Therapy of Ulcerative Colitis and Metastatic Colorectal Cancer, Neha Kumari

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Elucidating the Mechanism of the Polymeric Drug PAMD-CH17’S Novel Anti-Leukemic Effects, Calvin Lam

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Targeting TREM1: A Novel Therapeutic Approach to Mitigate Necrotizing Enterocolitis Injury in Murine Neonates, Zainab Damilola Lawal

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The Impact of Teaching Multiple Responses on Resurgence of Target Behavior and Persistence of Alternative Responding, Brittany H. Loder-Lafferty

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Improving Safety in Magnetic Resonance Imaging: A Grounded Theory Approach to Exploring the Perceptions of Technologists and Magnetic Resonance Safety Officers in Pediatric Settings, Stephanie Dawn Lough

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Peripheral Blood Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease, Brent A. Luedders

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Drivers and Mechanisms of Golgi Fragmentation as a Modulator of Disease, Amanda Macke

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Design and Synthesis of FDI-6-Based Hydrophobic Tag Degraders Targeting FOXM1, Callie J. Martin

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Climate Change and Infectious Disease Dynamics in the U.S.: Spatial-Temporal Patterns and Epidemiological Insights, Raheleh Mohammadi

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Evaluating the Therapeutic Potential of Geranylgeranyl Diphosphate Synthase Inhibitor, RAM2061, in Myeloma Bone Disease, Molly Muehlebach

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Demystifying Tumor-Mediated Local and Systemic Immunosuppression in Pancreatic Ductal Adenocarcinoma, Clara Mundry

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The Role of Cell Size and Proliferation in Intestinal Crypt Organization, Rosemary M. Mwithiga

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Evaluating BMX-001 as a Selective Radioprotector for Healthy Tissue in Pelvic Cancers, Molly Myers

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Symptom Clusters and their Association with Health-Related Quality of Life in Pediatric Cancer Survivors After Treatment Completion, Krishtee Napit

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Causal Mediation Analysis with Joint Modeling Framework for Recurrent Events Mediator and Survival Outcomes, Fang Niu

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Molecular Mechanisms of Aberrant Metabolism in Pancreatic Cancer Aggressiveness and Metastasis, Ayoola Ogunleye

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Cholestasis and Fluid Flow are Biomechanic Regulators of Cholangiocarcinoma Progression, Andrew Oleksijew

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Effects of Treatment Integrity Level and Error Type on Dro Efficacy: A Parametric and Comparative Analysis, Paige O'Neill

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Combinatorial Antiviral Regimen as Strategy to Control SARS-CoV-2 Infections, Kabita Pandey

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Novel Drug Delivery Platforms for Small Molecule and miRNA-Based Therapies in Acute Myeloid Leukemia, Qiaoyu Pan

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Optimizing Geranylgeranyl Diphosphate Synthase Inhibitor (GGSI) Therapy for Multiple Myeloma, Ashruti Pant

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Study of Peptide Amphiphiles as Antimicrobial Agents, Aramis J. Pereira

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Facilitating Professional Identity Development and Sense of Belonging in Cancer Research Doctoral Students, Misty S. Pocwierz-Gaines

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Eating the Fat of the Land: The Work of Coxiella burnetii To Traverse Intracellular Lipid Landscapes, Charlie Porto

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Claudin-1-Mediated Signaling and Therapy Resistance in Colorectal Cancer: From Mechanism to Translation, Mark W. Primeaux

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Dissecting MUC16 in Pancreatic Cancer: Imaging Targetability, Oncogenic Signaling and Immune Suppression, Christabelle Rajesh

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Decoding IPMN: Exploring the Molecular Bridges of Pancreatic Cancer Progression, Pratima Raut

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Viral Aerosols in Laboratory and Medical Environments: Generation, Detection, and Mitigation, Ashley R. Ravnholdt

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Disrupted Rhythms: The Impact of Altered Neural Oscillations and Sleep Patterns on Cognitive Impairment and Amyloid Accumulation in Alzheimer’s Disease, Maggie Rempe

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Investigating the Role of Androgen Deprivation on AXL Regulation in Prostate Cancer, Amanda Robotham

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Assessing Non-Technical Skills in Objective Structured Teaching Encounters: What Can Be Assessed and What is the Role of Artificial Intelligence-Based Grading?, Priscila Rodrigues Armijo

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Apolipoprotein E4, Tauopathy, and Brain Injury: Molecular Insights into Alzheimer's Disease Pathology, Nashanthea J. Roland

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Validating the Ability of IAG933 to Block the Interaction of YAP1 and TEAD in Ovarian Cancer Cells, Alex Sage

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Targeting Metabolic and Heme Degradation Pathways in Prostate Cancer: A New Therapeutic Strategy, Dania Sahtout

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Cross-Cultural Care in Perinatal Nursing, Erin Salahshurian

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Cardiovascular Disease Risk, Risk Factors, and Healthcare Utilization Among Latino Male Migrant Farmworkers in Nebraska, Maria Jose Sanchez Roman

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Analyzing Food Access: An Investigation of Food Insecurity amongst Latinos in Rural Nebraska, Natalia Santos

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Characterization and Identification of Staphylococcus Aureus Pyruvate Transporters, Cleofes Sarmiento

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Multilineage Hematopoietic Function of SAM-Containing Proteins, Meg Schaefer

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Staphylococcus aureus Encodes Multiple Arginine Transporters, Gabrielle Schulze

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Identification and Preclinical Assessment of Novel Therapeutic Modalities in Environmental Exposure-induced Lung Disease, Aaron D. Schwab

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Analysis and Modeling of the Liver Metastatic Niche in Pancreatic Cancer, Caroline Seilstad

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Targeting Human Bromodomain Proteins for the Treatment of Medulloblastoma, Zalak Sheth

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Development and Characterization of Non-Viral Delivery Systems for Pulmonary Delivery of Nucleic Acid Therapeutics, Kasturi Siddhanta

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Evaluation of the Gut Microbiome in Chronic Lymphocytic Leukemia: Disease Insights and Potential Therapeutic Avenues, Sydney Skupa

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Coxiella burnetii Manipulation of Membrane Contact Sites in the Intracellular Niche, Margaret F. Sladek

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Multimodal Longitudinal Assessment of the Developmental Trajectory of Resting State Connectivity and Neural Oscillatory Dynamics Supporting Executive Function, Jake Son

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MUC16 Rewires Metabolic Key Factors Through HKDC1 in the Progression of Pancreatic Ductal Adenocarcinoma, Katelyn D. Thompson

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A Replication and Extension of the Enhanced Choice Model for Children Who Exhibit Challenging Behavior, Jessica Tran

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The Characterization of Per- and Polyfluoroalkyl Substances (PFAS) in Nebraska Drinking Water and Human Health Impacts, Sarah Tucker

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Mucin-type O-glycans Protects Against Pancreatitis, Khadija Turabi

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Behavior Analysts’ Training and Practices Regarding Cultural Diversity: A Replication and Extension, Tania M. Valdez-Nuguid

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Immunoplasticity: A Key Determinant in the Outcome of Neurosurgical Biofilm Infection, Zachary A. Van Roy

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Deciphering Mechanisms of Mitoxantrone Action in Homologous Recombination Deficient Ovarian Cancer, Savanna A. Wallin

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Variable Selection with False Discovery Rate Control in High-Dimensional Data, Runqiu Wang

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Scientist Perspectives: A Correlation Analysis of Translational Science Competencies Compared with Principles of Engagement and Knowledge Integration, Rachel Wenzl

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Multilevel Considerations for Youth Attention-Deficit/Hyperactivity Disorder Prognosis and Management: Examining the Relationship between Health Care Factors and Familial Factors in Families of Children and Adolescents with ADHD, Carey A. Wheelhouse

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The Chlamydia trachomatis Inclusion Membrane as the Confluence between a Pathogen and Its Host, Ray E. Widner

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Facilitators of Routine Cervical Screening Receipt for Women With Intellectual and Developmental Disabilities in Nebraska, Anne Woodruff Jameson