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Theses/Dissertations from 2023

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Design, Synthesis, and Evaluation of Novel Peptidomimetics as Neurolysin Activators for the Treatment of Ischemic Stroke., Md. Shafikur Rahman

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SAMD14 Mechanisms in Stress Erythropoiesis, Suhita Ray

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Synergetic Signaling Between the Chlamydia Secreted Effectors TarP and TmeA Regulates Actin Kinetics and Efficient Entry, Matthew Romero

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A Community-Based Participatory Research Approach to Addressing Pediatric Asthma Disparities in Douglas County, Nebraska, Aislinn Rookwood

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Investigating Plasmodial Proteostasis Mechanisms to Counter Artemisinin Resistance, Melissa Rosenthal

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Understanding the Effect of Chikungunya Virus Infection on Bone Homeostasis, Enakshi Roy

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Oxidative Damage together with Post-Occlusive Re-Oxygenation Kinetics, in Calf Muscle, Implicate Microvessels in the Myopathy of Peripheral Artery Disease, Molly Schieber

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Towards a Mode of Action for the Anti-Schistosomal Aryl Hydantoins, Thomas Schulze

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Investigating and Targeting Iron Metabolism in Pseudomonas Aeruginosa and Klebsiella Pneumoniae, Zachary Scott

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Targeted Therapies for Improving the Treatment of Sonic Hedgehog and MYC Driven Medulloblastoma, Bharti Sethi

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A Multiple Methods Study to Describe the Manifestation of Burnout of Nebraska Physical Therapists, Nicole M. Sleddens

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Inter-Rater Reliability of Statistics Based on Reconstructed Individual Patient Data from Published Kaplan-Meier Curves, Megan E. Smith

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Understanding Healthcare Worker Experiences and Personal Protective Equipment (PPE)-Related Skin Reactions/Injuries During the COVID-19 Pandemic: A Mixed Methods Approach, Susan Solmos

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Variations in Source and Pattern of Arterial Supply to the Trigeminal Ganglion with Clinical Relevance, William S. Srinivasan

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Intramuscular Administration of the Host-Derived Immunostimulant CPDI-02 Increases Protection of Outbred Mice and Piglets Against Dermal MRSA Infection in a Curative Setting and is Well Tolerated After Repeated Administration, Jason P. Stewart

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Design and Synthesis of Small Molecule Drugs for CNS Disorders, Kirsten T. Tolentino

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Overcoming Resistance Mechanisms to CDK4/6 Inhibitor Treatment Using CDK6-Selective PROTAC, Sarah Truong

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Evaluating the Impact of Routine Enteral Iron Fortification on Gastrointestinal Dysbiosis in Premature Infants, Matthew Van Ormer

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Dynamics of Site Search Process and Formation of Synaptosome Assembly Characterized by Single Molecule Approaches, Sridhar Vemulapalli

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An Exploration of Policies, Equity, and Emerging Threats to the Traffic Safety Environment in the U.S., Sachi Verma

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Feasibility of a Laboratory Model for Evaluating the Use of an Alternative Response Option in Mitigating Caregiver Treatment Integrity Errors, Jessie K. Weber

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A Critical Assessment Of The Role Of ClpXP-Mediated Proteolysis In The Development and Differentiation Of Chlamydia trachomatis, Nicholas A. Wood

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Statistical Methods for Semi-Competing and Competing Risks Data with Missing Event Types, Ruiqian Wu

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Design, Synthesis, and Characterization of Peptide Amphiphile Biomaterials, Huihua Xing

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Polycationic Nanoparticle Delivery of Nucleic Acids for the Treatment of Fibrosis in Alcohol-Associated Liver Diseases, Chuhan Zhang

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Cardiac Vagal Dysfunction and Ventricular Arrhythmogenesis in Type 2 Diabetes Mellitus After Myocardial Infarction, Dongze Zhang

Theses/Dissertations from 2022

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Metoprolol Disrupts Sterol Biosynthesis through Inhibition of 7-Dehydrocholesterol Reductase (DHCR7), Luke B. Allen

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Facilitating the Emergence of Intraverbal-Tacts in Autistic Children Via Joint Control, Michael Aragon

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Transcranial Direct Current Stimulation of Frontal/Occipital Cortices Modulates Neural Correlates of Cognition in Healthy Young Adults, Yasra Arif

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Metagenome-Wide Associations and Metabolic Modeling to Predict the Biomarkers for Colorectal Cancer, Nagavardhini Avuthu

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Biologically-Inspired Nanoparticles For Oncology Applications, Aishwarya Bapat

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Targeted Therpeutics for Prostate Cancer, Behind the Scenes of PSMA & Cysteine Protease Trapping Mechanism, Alireza Basiri

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Astrocytic Contribution to Sensory Hypersensitivity in a Mouse Model of Fragile X Syndrome, Lara E. Bergdolt

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Aberrant Age-Related Alterations in Spontaneous Cortical Activity in Participants with Cerebral Palsy, Hannah Bergwell

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Exploring the Influence of Contextual Factors and the Caregiving Process on Burden, Quality of Life, and Outcomes of Heart Failure (HF) Dyads After a Hospital Discharge Guided by the Individual and Family Self-Management Theory (IFSMT): A Mixed Method Study, Tamara Bernard

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Polymeric Nanocarriers for Delivery of Small Molecules Inhibiting Tubulin Polymerization for the Treatment of Pancreatic Cancer and Lung Metastatic Melanoma, Rajan Sharma Bhattarai

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Grip Characterization of Protective Gloves, Doris Burns

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A Cell Culture Model to Study Tobacco Associated Oral Cancer Progression and Treatment Resistance, Amanda Busch

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The State of Oral Health in People with Disabilities and the Impact of Family-Centered Care on the Oral Health of Children with Special Health Care Needs, Bedant Chakraborty

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Modulating Cardiac Remodeling After Myocardial Infarction, Upendra Chalise

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The Development of Thermoresponsive Hydrogel-Based Drug Delivery Systems for the Treatment of Musculoskeletal Diseases, Ningrong Chen

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Omics Analysis in Cancer and Development, Emalie J. Clement

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Leukocyte Subsets in the Peripheral Blood and Spleen of Gastrointestinal Cancer Patients, Kathryn E. Cole

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Roles of C-Terminal Domain of DNA Polymerase ζ Catalytic Subunit, Rev3, in Translesion Dna Synthesis and Origin of Mutations in Yeast, Jian Cui

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Mechanisms of Sorting and Fission at the Endosomes, Kanika Dhawan

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The Link Between Fat Soluble Vitamin Deficiencies, Decreased Microbiota Diversity and Severity in Children with Sickle Cell Disease Followed in a Clinic in Omaha Nebraska, Chinenye R. Dike

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Development of Perfluorocarbon Nanoemulsions for Delivery of Therapeutic Nucleic Acids, Ling Ding

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Linking spinal cord circuits with upper limb sensorimotor control in adults with cerebral palsy, Saihari Dukkipati

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Evaluation of Awareness, Knowledge, and Preventive Intervention of Nonalcoholic Fatty Liver Disease Among Chinese Young Adults, Yi Du

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Psychological Trauma Alters T-lymphocyte Inflammation and Redox Through Sympathetic Mechanisms, Safwan K. Elkhatib

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Teaching Children with Autism Spectrum Disorder Self-Protection Skills in Response to Bullying Situations, Maya J. Fallon

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Feasibility and Efficacy of Bisphosphonate Use for the Prevention of Bone and Muscle Loss, Laura E. Flores

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Role of E3 Ubiquitin Ligase UBR5 in B Cell Development and Mantle Cell Lymphoma, Tyler J. Gilbreath

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A systematic literature review of the prevalence, distribution, exposure, and human health risks of tire microplastics and the contribution of their physicochemically diverse properties, Luke Glastad

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Investigating the Role of Splenic Macrophages in Pancreatic Cancer, Daisy V. Gonzalez

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ERα as a Modulator of the Sle1b Lupus Susceptibility Locus and B Cell Receptor Signaling, Jared H. Graham

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Investigation of Cumulative Genetic Risk and CC16 in Adult Asthma and COPD Populations, Kelli C. Gribben

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Characterizing a MUC4-Based Nanovaccine and Enhancing its Efficacy by Targeting the Endothelin Axis, Mansi Gulati

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Prenatal and Pregnancy Loss Evaluation by Noninvasive Screening and Diagnostic Genetic Testing, Abigail Haggerty

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Extracellular Mechanotransduction in Marfan Syndrome: An Equivalence Principle, Stephen Haller

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Frailty and Neurocognition in Prostate Cancer, Lindsey Hanson

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Regulation of Pancreatic Cancer Progression by Micronutrients, Chunbo He

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Neuropilin-2 in Advanced Prostate Cancer and its Targeting with Novel Small Molecule Inhibitors, Ridwan Islam

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Structural and Biochemical Studies of Three Enzymes Involved in Amino Acid Metabolism to Develop Novel Drugs, Yahani Pankaja Jayasinghe Arachchige

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Structural and Inhibitory Studies on (i)Two Mycobacterium Tuberculosis Enzymes Essential for Capsular Glucan Biosynthesis and mRNA Degradation: (Ii) Hantann Virus L-Protein Endonuclease Domain, Hettiarachchige Thilina D. Jayasinghe

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An Analysis of the Genetic and Environmental Mechanisms behind Aortic Aneurysm Development and Inhibition, Kathryn E. Jespersen

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Aerosols in Orthodontics: Characterization of Particle Size and Travel Distance, Donte Jochum-Nesbitt

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Strengthening Capacity for Clinical and Translational Science: A Multi-Method Assessment of Research Capacity Development in a Regional Clinical and Translational Research Network, LaKaija Johnson

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Gut Commensals Modulate SIV/SHIV Pathogenesis and Therapeutics, Samuel Johnson

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Novel Molecular Mechanisms of C-Terminal Eps15 Homology Domain (EHD) Proteins in Endocytic Trafficking and Primary Ciliogenesis, Tyler M. Jones

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Determining the Role of miR-133a in the Diabetic Heart, Tyler Kambis

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Polymeric Chloroquine in Metastatic Pancreatic Cancer Therapy, Rubayat Islam Khan

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Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer, Shelby M. Knoche

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Returning to Life Activities after Hematopoietic Cell Transplantation in Older Adults, Thuy T. Koll

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Ewing Sarcoma Transcriptome: Identification of FOXN3 as a Novel Target of EWS-FLI1, Natasha Kreiling

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Mental Health Promotion, Early Identification & Treatment Services and Supports in Public K-12 School Districts: Three Case Studies to Explore Available Resources, Interventions, and Community Partnerships, Keenan Krick

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Formal Caregiver Burden among Nursing Assistants in Nursing Homes: A Mixed Methods Study, Rachel Kunkle

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Understanding the Perceived Risk and Biopsychosocial Impact of the COVID-19 Pandemic on People Living with HIV and Pre-Exposure Prophylaxis Users in Nebraska: A Mixed Methods Approach, Titilola O. Labisi

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Increasing Young Children’s Honest Reports and Decreasing Their Transgressions, Robert K. Lehardy

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The Role of Parkin in Mitochondrial DNA, Eliezer Lichter

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Overcome Resistance to Drug-Induced Apoptosis in Cancer Cells, Jian Li

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Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells, Cassie Liu

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Novel Mechanisms of Protein Kinase C α Regulation and Function, Xinyue Li

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Macromolecular Fluorescent Conjugates for Bioimaging Applications, Paul Lovell

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Essential Protections for Essential Workers: Ethical Considerations for Infection Prevention and Control, Abigail E. Lowe

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Underlying Mechanism of Ovarian Reserve Preservation from Gonadotoxicity, Yi Luan

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Assessing the Methodology, Prevalence, and Associated Factors for Adverse Childhood Experiences (ACEs) Among Children and Adolescents in the United States, Kiara L. Lyons

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CRISPR Technology as an Antiviral in dsDNA and ssRNA Viruses, Cathryn Mayes

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Mobile, Biosensor Technology for Measuring Joint-Level Human Motion, Matthew McManigal

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SOX2 Dosage Governs Tumor Cell Identity and Proliferation, Ethan P. Metz

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The Effect of Interproximal Home Regimens of Inflammatory Biomarkers in Periodontal Maintenance Patients, Grace Moore

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Exploring Host-Pathogen Interactions of the Ebola Virus Ribonucleoprotein Complex, M. Jane Morwitzer

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The Role of Calprotectin in T-Lymphocyte Driven Inflammation in a Mouse Model of Psychological Trauma, Cassandra Moshfegh

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Innate Immunity in the Pathobiology and Treatment of Infectious and Neurodegenerative Diseases, Mai Mostafa

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Hepatocyte-Hepatic Stellate Cell Axis in Potentiation of Alcohol and HIV-Induced Liver Injury, Moses O. New-Aaron

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Modulating Cellular Senescence to Improve Age-Associated Wound Healing Impairment, Upasana Niyogi

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Agrichemicals (Nitrate and Atrazine) In Drinking Water and Adverse Health Outcomes in Children in Nebraska, Balkissa S. Ouattara

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Establishing a generalized qualifying autoclitic repertoire in children with autism spectrum disorder, Todd M. Owen

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Investigating the Role of Sphingosine Kinases During Alphavirus Infection, Opeoluwa Oyewole

Investigating the Role of Sphingosine Kinases During Alphavirus Infection, Opeoluwa Oyewole